In Brachyspira pathogenesis, what is the final mucosal change described?

In Brachyspira pathogenesis, what is the final mucosal change described?

• A. Hypersecretion of mucus by mucosal epithelium
• B. Degeneration and inflammation of superficial mucosa
• C. Deep tissue invasion
• D. Necrosis of the intestinal wall

Answer: (A)

Brachyspira infections drive a mucosa-centered inflammatory response in the colon. As the disease progresses, the mucosal lining responds by increasing mucus production, with goblet cells proliferating and secreting大量 mucus. This results in a thick, mucus-rich coating on the surface, which is the final mucosal change described in the pathogenesis. The organisms are not typically invasive into deeper tissues, so deep tissue invasion or extensive necrosis aren’t the defining outcomes. Early changes involve irritation and inflammation of the superficial mucosa, but the characteristic endpoint is hypersecretion of mucus by the mucosal epithelium.

Brachyspira infections drive a mucosa-centered inflammatory response in the colon. As the disease progresses, the mucosal lining responds by increasing mucus production, with goblet cells proliferating and secreting大量 mucus. This results in a thick, mucus-rich coating on the surface, which is the final mucosal change described in the pathogenesis. The organisms are not typically invasive into deeper tissues, so deep tissue invasion or extensive necrosis aren’t the defining outcomes. Early changes involve irritation and inflammation of the superficial mucosa, but the characteristic endpoint is hypersecretion of mucus by the mucosal epithelium.